DONERGEST 10 (Dydrogesterone 10 mg Tablets)

Description

DESCRIPTION:
Donergest 10 contains Dydrogesterone 10 mg, a synthetic form of the natural female hormone progesterone. It is used to treat various disorders caused by progesterone deficiency and to support normal reproductive function in women. Dydrogesterone helps regulate the menstrual cycle, maintain the uterine lining, and support early pregnancy by mimicking the actions of natural progesterone.

Donergest 10 is indicated for the management of menstrual irregularities, secondary amenorrhoea, dysmenorrhoea, endometriosis, and luteal phase insufficiency. It is also used as part of hormone replacement therapy (HRT) and to support pregnancy in women experiencing threatened or recurrent miscarriage due to progesterone deficiency.

MECHANISM OF ACTION:
Dydrogesterone acts on the endometrium (lining of the uterus) to restore normal secretory transformation, helping regulate menstrual bleeding and promoting a healthy uterine environment. Unlike some other progestogens, dydrogesterone has no androgenic, estrogenic, or glucocorticoid effects, making it well tolerated and physiologically selective for progesterone receptors.

USES:

• Regulation of menstrual cycle disorders (irregular or painful periods)
• Treatment of endometriosis
• Management of secondary amenorrhoea
• Treatment of premenstrual syndrome (PMS)
• Support of early pregnancy and prevention of miscarriage due to progesterone deficiency
• Adjunct therapy with estrogen in hormone replacement therapy (HRT)

MEDICINAL BENEFITS:

• Restores hormonal balance in women with progesterone deficiency
• Regulates normal menstrual flow and relieves menstrual pain
• Helps manage endometrial growth in endometriosis
• Supports implantation and pregnancy maintenance
• Well tolerated with minimal hormonal side effects

DOSAGE & ADMINISTRATION:
Dosage and duration of therapy should be individualized based on the indication and clinical response. The usual adult dose is one tablet (10 mg) once or twice daily, or as directed by the physician. Swallow the tablet whole with a glass of water, with or without food. Continue treatment as advised by your healthcare provider.

STORAGE:
Store in a cool, dry place below 25°C. Protect from light and moisture. Keep out of reach of children.

CONTRAINDICATIONS:

• Hypersensitivity to Dydrogesterone or any excipients in the formulation
• Known or suspected hormone-dependent malignancy
• Undiagnosed vaginal bleeding
• Severe liver disease or hepatic dysfunction

WARNINGS & PRECAUTIONS:

• Use with caution in patients with a history of liver disorders or depression
• Regular medical supervision is recommended during prolonged therapy
• Should not be used for contraception
• Use in pregnancy and lactation only under medical supervision

SIDE EFFECTS:
Most patients tolerate Dydrogesterone well. Occasionally, mild side effects such as headache, breast tenderness, nausea, abdominal discomfort, or mood changes may occur. These are generally mild and transient. Consult your doctor if any side effects persist.

DISCLAIMER:
Donergest 10 should be used strictly under medical supervision. The dosage and duration should be as directed by a qualified healthcare professional based on the patient’s medical condition.