GLIMITATE M 2
COMPOSITION:
GLIMITATE M 2
Each Uncoated bilayer tablet contains
Glimepiride………………………………2 mg
Metformin (Sustain-Release)……… 500 mg
Glimitate M2 is with a combination of GLIMEPIRIDE 2mg +METFORMIN 500 mg SR Tablets belong to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance).
Glimitate M2 is with a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin SR is a Sustained-release formulation that releases the drug in smaller portions over a longer duration of time. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood.
Take GLIMEPIRIDE+METFORMIN as prescribed by your doctor. You are advised to take GLIMEPIRIDE+METFORMIN for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of GLIMEPIRIDE+METFORMIN do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to GLIMEPIRIDE+METFORMIN or any other medicines, please tell your doctor. GLIMEPIRIDE+METFORMIN is not recommended for children. Avoid breastfeeding while taking GLIMEPIRIDE+METFORMIN as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking GLIMEPIRIDE+METFORMIN as it may harm the unborn baby. Avoid alcohol consumption with GLIMEPIRIDE+METFORMIN as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking GLIMEPIRIDE+METFORMIN. Take short, frequent meals and avoid prolonged fasting while taking GLIMEPIRIDE+METFORMIN.
Uses of Glimitate M2
In Type 2 diabetes mellitus
Medicinal Benefits
Glimitate M2 contains Glimepiride 2mg and Metformin 500mg used in the treatment of type 2 diabetes. Glimepiride stimulates cells in the pancreas that produce insulin which helps to remove sugar from the blood. Metformin PR is a prolonged-release formulation that releases the drug in smaller portions over a longer duration of time. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood.
DOSAGE & ADMINISTRATION:
General
Dosage should be individualized on the basis of both effectiveness and tolerance. The combination should be given once daily (daily) with meals and should be started at a low dose. The initial recommended dose is one tablet once daily with breakfast or the first main meal of the day and gradually titrated after assessing the adequacy of the therapeutic response.
Directions for Use
Take GLIMITATE M2 as advised by your doctor. Swallow it as a whole with a glass of water. Do not crush or break it.
Storage
Store in a cool and dry place away from sunlight
CONTRAINDICATIONS:
1. Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels 1.5 mg/dL [males], 1.4 mg/dL [females] or abnormal creatinine clearance), which may also result from condition s such as cardiovascular collapse (shock), acute myocardial infarction, and septicaemia.
2. Congestive heart failure requiring pharmacologic treatment.
3. Known hypersensitivity to this product or any of its components.
4. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Diabetic ketoacidosis should be treated with insulin.
5. Patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because the use of such products may result in acute alteration of renal function.
